Potassium Carbonate → HCID 86692256, compound

HRID 1469769Notes

Reaction equation

HRID 1469769 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[F:15][C:16]([F:25])([F:24])[C:17]1[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=1.C([O-])([O-])=O.[K+].[K+]>CC#N>[N+:12]([C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[CH:5]=[CH:4][N:3]=[C:2]2[O:23][C:20]1[CH:21]=[CH:22][C:17]([C:16]([F:15])([F:24])[F:25])=[CH:18][CH:19]=1)([O-:14])=[O:13]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 678744-(Trifluoromethyl)phenolHCID 4597741-Chloro-5-nitroisoquinoline

Product 1

HCID 86692256HCID 86692256, compoundYield 100.1%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound was prepared following the procedure described in Intermediate-6, step-1 using 1-chloro-5-nitroisoquinoline (Step-1, Intermediate-1, 500 mg, 2.39 mmol), 4-(trifluoromethyl)phenol (776 mg, 4.79 mmol) and K2CO3 (989 mg, 7.17 mmol) in CH3CN (5 mL) to afford 800 mg of the title product. MS (m/z): 335.09 (M+H)+.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-ee12568beee94b228ec53807096ec3da
Source dataset
uspto-grants-2015_04
Patent number
US09006257B2

Reaction notes

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