Morpholine → HCID 71678382, compound

HRID 1469780Notes

Reaction equation

HRID 1469780 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:15])[N:3]=1.[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1.C([O-])([O-])=O.[K+].[K+]>CC#N>[CH3:15][C:4]1[N:3]=[C:2]([N:16]2[CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)[C:11]2[C:6](=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=1

Participants

5

Reactant 3

HCID 8083MorpholineHCID 11430Potassium CarbonateHCID 86692243HCID 86692243, compound

Product 1

HCID 71678382HCID 71678382, compoundYield 78.1%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound was prepared following the procedure described in Intermediate-15, step-1 using 4-chloro-2-methyl-8-nitroquinazoline (Intermediate-27, step-2, 280 mg, 1.26 mmol), morpholine (219 mg, 2.52 mmol), and K2CO3 (521 mg, 3.78 mmol) in CH3CN (5 mL) to afford 270 mg of the title product. MS [M+H]+: 275.22.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-688a1bc29327439d877f343531dfb110
Source dataset
uspto-grants-2015_04
Patent number
US09006257B2

Reaction notes

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