Tert-Butylamine → HCID 86692261, compound

HRID 1469784Notes

Reaction equation

HRID 1469784 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:15])[N:3]=1.[C:16]([NH2:20])([CH3:19])([CH3:18])[CH3:17]>N1C=CC=CC=1>[C:16]([NH:20][C:2]1[C:11]2[C:6](=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:15])[N:3]=1)([CH3:19])([CH3:18])[CH3:17]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 86692243HCID 86692243, compound

Product 1

HCID 86692261HCID 86692261, compoundYield 57.3%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The title compound was prepared following the procedure described in Intermediate-55, step-1 using 4-chloro-2-methyl-8-nitroquinazoline (Intermediate-27, step-2, 300 mg, 1.34 mmol), and tert-butylamine (196 mg, 2.68 mmol) in pyridine (5 mL) to afford 200 mg of the title product. 1H NMR (300 MHz, DMSO d6): δ 8.62-8.59 (d, J=8.1 Hz, 1H), 8.16-8.13 (d, J=7.5 Hz, 1H), 7.61 (s, 1H), 7.51 (t, J=7.8 Hz, 1H), 2.45 (s, 3H), 1.55 (s, 9H); MS (m/z): 261.20 (M+H)+.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-7ff243e7a6d34cccb4b9f0a1656b85d2
Source dataset
uspto-grants-2015_04
Patent number
US09006257B2

Reaction notes

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