Hydrochloric Acid → HCID 58073809, compound

HRID 1470587Notes

Reaction equation

HRID 1470587 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10]([N+:12]([O-:14])=[O:13])[CH:11]=1)[NH:8]C(=O)[C:6]2=[O:16].[OH:17]O.Cl>[OH-].[Na+]>[NH2:8][C:9]1[C:10]([N+:12]([O-:14])=[O:13])=[CH:11][C:3]([O:2][CH3:1])=[CH:4][C:5]=1[C:6]([OH:16])=[O:17]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 3682022HCID 3682022, compound

Product 1

HCID 58073809HCID 58073809, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

To a slurry of 5-methoxy-7-nitro-1H-indole-2,3-dione (3 g, 13.5 mmol) in aqueous 2N NaOH solution (30 mL), was added an aq. Solution of 33% hydrogen peroxide (3 mL) slowly at 0° C. After completion of the addition, the reaction mixture was stirred at room temperature for 4 h. After completion of the reaction, the reaction mixture was acidified with 2N HCl at 0° C. The resulting precipitate was filtered, washed with water (2-3 times) and dried under vacuum to obtain the title compound as yellow solid which was directly used for the next reaction.

Workup

  1. additionAfter completion of the addition
  2. customAfter completion of the reaction
  3. filtrationThe resulting precipitate was filtered
  4. washwashed with water (2-3 times)
  5. customdried under vacuum

Sources & evidence

ORD record
ord-40d914993b29483cbb87013984923a88
Source dataset
uspto-grants-2015_04
Patent number
US09006454B2

Reaction notes

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