反应详情

A mixture of 3-trifluoromethyl-phenylamine (4 g, 24.8 mmol), acetic anhydride (10.1 g, 99.3 mmol), DMAP (0.9 g, 7.4 mmol) and triethyl amine (2.5 g, 24.8 mmol) was heated to reflux 2 h. After completion of the reaction, the reaction mixture was cooled to room temperature, diluted with water, extracted with ethyl acetate, and the combined organic layers were dried over sodium sulphate and concentrated to dryness. The obtained residue was purified by column chromatography using 30% ethylacetate in hexane to get the title compound as off-white solid.

1. temperaturewas heated
2. temperatureto reflux 2 h
3. customAfter completion of the reaction
4. extractionextracted with ethyl acetate
5. dry with materialthe combined organic layers were dried over sodium sulphate
6. concentrationconcentrated to dryness
7. customThe obtained residue was purified by column chromatography