Hydrochloric Acid → 2-Amino-3-iodobenzoic acid
Reaction equation
[I:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9]C(=O)[C:7]2=[O:12].[OH-:13].[Na+].OO.Cl>O>[NH2:9][C:10]1[C:2]([I:1])=[CH:3][CH:4]=[CH:5][C:6]=1[C:7]([OH:12])=[O:13]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
To a ice cold solution of 7-iodoindoline-2,3-dione (2.9 g, 0.0106 mol) in an aq. solution of 2 N NaOH (15 mL) was added drop wise an aq. solution of 35% H2O2 (3 mL) and then allowed to stir at room temperature over night. After the reaction is completed, the reaction mixture was diluted with water (50 mL), adjusted the pH to 2 with conc. HCl.
Sources & evidence
- ORD record
- ord-8808306e31ff4ec789847f08971140e7
- Source dataset
- uspto-grants-2015_04
- Patent number
- US09006454B2
Reaction notes
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