Hydrochloric Acid → HCID 67125457, compound

HRID 1470725Notes

Reaction equation

[ClH:1].C(OC(=O)[NH:8][C@H:9]([C:11]1[CH:16]=[CH:15][C:14]([CH:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[CH:27][C:26]([O:29][CH2:30][CH3:31])=[CH:25][CH:24]=3)[CH2:19][CH2:18]2)=[CH:13][CH:12]=1)[CH3:10])(C)(C)C>CO.ClCCl>[ClH:1].[ClH:1].[CH2:30]([O:29][C:26]1[CH:25]=[CH:24][C:23]([N:20]2[CH2:19][CH2:18][CH:17]([C:14]3[CH:13]=[CH:12][C:11]([C@@H:9]([NH2:8])[CH3:10])=[CH:16][CH:15]=3)[CH2:22][CH2:21]2)=[CH:28][CH:27]=1)[CH3:31]

Participants

Conditions

Temperature: 50 °C

Procedure

11.3 mL (14.1 mmol) 1.25 N HCl in methanol are added to 900 mg (2.12 mmol) (S)-(1-{4-[1-(4-ethoxy-phenyl)-piperidin-4-yl]-phenyl}-ethyl)-carbamic acid tert-butyl ester (XII.1) in 25 mL dichloromethane. The mixture is stirred for 14 h at rt and for 1 h at 50° C. After that time, the solvent is removed in vacuo to yield the desired product.

Workup

customAfter that time, the solvent is removed in vacuo

Sources & evidence

ORD record: ord-36291e46ba5f46a78d7bcb981a8d3deb
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09006450B2

Reaction notes

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