HCID 178526811, compound → HCID 178508024, compound

HRID 1470728Notes

Reaction equation

HRID 1470728 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([OH:8])[C:5]([N+:9]([O-])=O)=[CH:4][N:3]=1>O=[Pt]=O.CO>[NH2:9][C:5]1[C:6]([OH:8])=[N:7][C:2]([Cl:1])=[N:3][CH:4]=1

Participants

4

Reactant 1

HCID 178526811HCID 178526811, compound

Product 1

HCID 178508024HCID 178508024, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 887MethanolSolvent

Procedure

25 g (126 mmol) 2-chloro-5-nitro-pyrimidin-4-ol, 2.0 g PtO2 and 2.5 L MeOH are hydrogenated (50 psi) for 1 h. The mixture is filtered and concentrated and dried to yield 5-amino-2-chloro-pyrimidin-4-ol.

Workup

  1. customfor 1 h
  2. filtrationThe mixture is filtered
  3. concentrationconcentrated
  4. customdried

Sources & evidence

ORD record
ord-4f471f7bce8a4c5fa4795c7e7b29e836
Source dataset
uspto-grants-2015_04
Patent number
US09006450B2

Reaction notes

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