反应详情

温度

100 °C

To 1.52 g (8.5 mmol) 2-chloropyrimidine-5-carboxylic acid methyl ester in 80 mL NMP are added 2.1 g (8.5 mmol (S)—N-[1-(4-piperidin-4-yl-phenyl)-ethyl]-acetamide (V.1) and 2.9 mL (17.1 mmol) DIPEA and the mixture is stirred for 4 h at 100° C. The solvent is removed in vacuo. The residue is treated with 100 mL MeOH and 10 mL 4N sodium hydroxide solution is added. The mixture is stirred for 1 h at 60° C. After cooling to rt 4N HCl solution is added until the pH is acidic. The precipitate is collected and dried to yield the desired product.

1. customThe solvent is removed in vacuo
2. additionThe residue is treated with 100 mL MeOH and 10 mL 4N sodium hydroxide solution
3. additionis added
4. stirringThe mixture is stirred for 1 h at 60° C
5. temperatureAfter cooling to rt 4N HCl solution
6. additionis added until the pH
7. customThe precipitate is collected
8. customdried