Benzyl Bromide → HCID 67125425, compound

HRID 1470734Notes

Reaction equation

HRID 1470734 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:12]=[CH:11][C:10]([C@@H:13]([NH:15][C:16](=[O:19])[CH2:17][CH3:18])[CH3:14])=[CH:9][CH:8]=2)=[CH:3][CH:2]=1.[CH2:20]([Br:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>CC(C)=O>[Br-:27].[CH2:20]([N+:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:12]=[CH:11][C:10]([C@@H:13]([NH:15][C:16](=[O:19])[CH2:17][CH3:18])[CH3:14])=[CH:9][CH:8]=2)=[CH:3][CH:2]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 7498Benzyl BromideHCID 67125383HCID 67125383, compound

Product 1

HCID 67125425HCID 67125425, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To 9.60 g (37.7 mmol) (S)—N-[1-(4-pyridin-4-yl-phenyl)-ethyl]-propionamide (IV.6) in 120 mL acetone are added 4.91 mL (41.5 mmol) benzyl bromide. The mixture is refluxed for 12 h. After that time, the precipitate is filtered off, washed with acetone and dried at 50° C. to yield the desired product.

Workup

  1. temperatureThe mixture is refluxed for 12 h
  2. filtrationAfter that time, the precipitate is filtered off
  3. washwashed with acetone
  4. customdried at 50° C.

Sources & evidence

ORD record
ord-00ddd8b6d4294c2383da69ed4fcd403c
Source dataset
uspto-grants-2015_04
Patent number
US09006450B2

Reaction notes

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