Hydrochloric Acid → HCID 86692647, compound

HRID 1470831Notes

Reaction equation

HRID 1470831 reaction equation
[F:1][C:2]1[C:3]2[CH2:12][S:11][CH2:10][C:4]=2[S:5][C:6]=1C(O)=O.Cl>N1C2C(=CC=CC=2)C=CC1=O>[F:1][C:2]1[C:3]2[CH2:12][S:11][CH2:10][C:4]=2[S:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66889872HCID 66889872, compound

Product 1

HCID 86692647HCID 86692647, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 60382-HydroxyquinolineSolvent

Conditions

Temperature
220 °C

Procedure

500 mg compound 6 from the previous step was mixed with 100 mg Cu powder and 20 ml quinolone. The mixture was heated at about 220° C. for about 2 hours. After cooling to about room temperature, the mixture was poured into 6 M HCl and extracted by ether 3 times. Compound 7 was dried by anhydrous Na2SO4. The yield was about 90%.

Workup

  1. temperatureAfter cooling to about room temperature
  2. extractionextracted by ether 3 times
  3. dry with materialCompound 7 was dried by anhydrous Na2SO4

Sources & evidence

ORD record
ord-1843643f27e74715aa264495889d2cfe
Source dataset
uspto-grants-2015_04
Patent number
US09006568B2

Reaction notes

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