Acetyl chloride → {Acetyl-[3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-phenyl]-amino}-acetic acid ethyl ester
Reaction equation
[CH2:1]([CH3:2])[O:3][C:4]([CH2:5][NH:6][c:7]1[cH:8][c:9]([CH2:13][O:14][c:15]2[cH:16][cH:17][c:18](-[c:21]3[c:22]([O:29][CH3:30])[cH:23][c:24]([F:28])[c:25]([F:27])[cH:26]3)[cH:19][cH:20]2)[cH:10][cH:11][cH:12]1)=[O:31].[CH3:32][Si:33]([N-:34][Si:35]([CH3:36])([CH3:37])[CH3:38])([CH3:39])[CH3:40].[CH3:51][C:52]([Cl:53])=[O:54].[CH:42]([N:43]([CH:44]([CH3:45])[CH3:46])[CH2:47][CH3:48])([CH3:49])[CH3:50].[Li+:41]>>[CH2:1]([CH3:2])[O:3][C:4]([CH2:5][N:6]([c:7]1[cH:8][c:9]([CH2:13][O:14][c:15]2[cH:16][cH:17][c:18](-[c:21]3[c:22]([O:29][CH3:30])[cH:23][c:24]([F:28])[c:25]([F:27])[cH:26]3)[cH:19][cH:20]2)[cH:10][cH:11][cH:12]1)[C:52]([CH3:51])=[O:54])=[O:31]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-ba0a2d82e5ee49528695685b9cbe0f8c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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