反应详情

温度

0 °C

To a solution of the product from Example 1B (0.80 g, 2.407 mmol) in dry CH2Cl2 (25 ml) at 0° C. was added triethylamine (1.007 ml, 7.22 mmol), followed by dropwise addition of methanesulfonyl chloride (0.469 ml, 6.02 mmol). The resulting mixture was stirred at 0° C. for 30 min, during which time the starting material slowly went into solution. After stirring an additional 1 h at 0° C., a precipitate began to form. Saturated aq NH4Cl (4 ml) was added, and stirring was continued at room temperature for 20 min. The mixture was washed with water (2×10 ml), and the organic layer was treated with hexanes (10 ml) to give an orange solid that was collected by filtration to give the title compound (0.75 gm, 64% yield).

1. stirringAfter stirring an additional 1 h at 0° C.
2. customto form
3. stirringstirring
4. waitwas continued at room temperature for 20 min
5. washThe mixture was washed with water (2×10 ml)
6. additionthe organic layer was treated with hexanes (10 ml)
7. customto give an orange solid
8. filtrationthat was collected by filtration