反应详情

The product from Example 99A (26.8 mg, 0.053 mmole) was dissolved in THF (526 L) in a round bottom flask to which was subsequently added ethanol (526 L) resulting in a yellow precipitate. To this suspension was added platinum (IV) oxide (3.16 mg, 0.014 mmole). The flask was capped with a septum and the contents vacuum degassed three times. Hydrogen was introduced via a balloon and the mixture allowed to stir at room temperature for two and one half hours. The reaction mixture was vacuum filtered through a sand and celite plug, which was rinsed with THF and methanol until the filtrate was u.v.(−). The filtrate was concentrated in vacuo to provide the title compound in quantitative yield as a white solid as a mixture of stereoisomers. MS ESI(+), m/z@450.7 (M+H)+.

1. customresulting in a yellow precipitate
2. customThe flask was capped with a septum
3. customthe contents vacuum degassed three times
4. additionHydrogen was introduced via a balloon
5. filtrationfiltered through a sand and celite plug, which
6. washwas rinsed with THF and methanol until the filtrate
7. concentrationThe filtrate was concentrated in vacuo