反应详情

To a flask were added 3 g 2-phenylbenzimidazole, 2.8 g potassium carbonate, 40 ml N,N-dimethylformamide and the mixture was stirred under nitrogen. 3.6 g Benzyl chloride were added and the mixture was heated to 75 C for 8 hrs. The reaction was cooled to 50 C and quenched with 40 ml of water and cooled to 5 C. The product was filtered, washed with water. The product was recrystallized by dissolving in 57 ml acetonitrile at reflux and 39 ml water were added. After cooling to 5 C, the product was filtered, washed and dried giving 3.1 g.

1. temperaturethe mixture was heated to 75 C for 8 hrs
2. temperatureThe reaction was cooled to 50 C
3. customquenched with 40 ml of water
4. temperaturecooled to 5 C
5. filtrationThe product was filtered
6. washwashed with water
7. customThe product was recrystallized
8. dissolutionby dissolving in 57 ml acetonitrile
9. temperatureat reflux
10. addition39 ml water were added
11. temperatureAfter cooling to 5 C
12. filtrationthe product was filtered
13. washwashed
14. customdried
15. customgiving 3.1 g