bis(hydroxymethyl)phosphinic acid → HCID 86619915, compound

HRID 1471256Notes

Reaction equation

HRID 1471256 reaction equation
[OH:1][CH2:2][P:3]([CH2:6][OH:7])(=[O:5])[OH:4].[OH-].[CH2:9]([N+:13]([CH2:22][CH2:23][CH2:24][CH3:25])([CH2:18][CH2:19][CH2:20][CH3:21])[CH2:14][CH2:15][CH2:16][CH3:17])[CH2:10][CH2:11][CH3:12]>O.CC(O)C>[OH:1][CH2:2][P:3]([CH2:6][OH:7])(=[O:4])[O-:5].[CH2:22]([N+:13]([CH2:9][CH2:10][CH2:11][CH3:12])([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:18][CH2:19][CH2:20][CH3:21])[CH2:23][CH2:24][CH3:25]

Participants

5

Reactant 2

HCID 237875bis(hydroxymethyl)phosphinic acidHCID 2723671Tetrabutylammonium Hydroxide

Product 1

HCID 86619915HCID 86619915, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3776IsopropanolSolvent

Procedure

To a flask were added 0.48 g bis(hydroxymethyl)phosphinic acid, 1.6 g of a 55-60% solution of tetrabutylammonium hydroxide in water and 10 ml 2-propanol. After heating to 50 C under nitrogen for 1 hour, the solvent was removed and another 10 ml of 2-propanol were added and removed by distillation under reduced pressure. An oil was obtained.

Workup

  1. temperatureAfter heating to 50 C under nitrogen for 1 hour
  2. customthe solvent was removed
  3. additionanother 10 ml of 2-propanol were added
  4. customremoved by distillation under reduced pressure
  5. customAn oil was obtained

Sources & evidence

ORD record
ord-6929cffb6bfd4d78922596aac4fdb7c9
Source dataset
uspto-grants-2015_04
Patent number
US09011734B2

Reaction notes

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