2-Fluoroethyl bromide → HCID 79035246, compound

HRID 1471432Notes

Reaction equation

HRID 1471432 reaction equation
[H-].[Na+].[Br:3][C:4]1[CH:5]=[N:6][NH:7][CH:8]=1.Br[CH2:10][CH2:11][F:12]>CN(C=O)C>[Br:3][C:4]1[CH:5]=[N:6][N:7]([CH2:10][CH2:11][F:12])[CH:8]=1

Participants

5

Reactant 3

HCID 129822-Fluoroethyl bromideHCID 163754-BromopyrazoleHCID 24758Sodium hydride

Product 1

HCID 79035246HCID 79035246, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

Sodium hydride (24.22 mg, 0.606 mmol, 60% suspension in mineral oil) was added to a solution of 4-bromo-1H-pyrazole (89 mg, 0.606 mmol) in DMF (3028 μl) at RT. After 15 min, 1-bromo-2-fluoroethane (100 mg, 0.787 mmol) was added to the mixture. After 30 min, the mixture was diluted with DMF and purified by HPLC, followed by neutralization (K2CO3), to afford the title compound as a colorless oil.

Workup

  1. waitAfter 30 min
  2. custompurified by HPLC

Sources & evidence

ORD record
ord-b3491ce9bf9f49b5b62fe6e6538dd1be
Source dataset
uspto-grants-2015_04
Patent number
US09012447B2

Reaction notes

Loading…