反应详情

温度

120 °C

To a solution of 3,6-dichloropyridazine (2.0 g, 13.42 mmole) in 1,4-dioxane (20 ml) are added Pd2(dba)3 (0.21 g, 0.2 mmole), P(tBu)3 (0.122 g, 0.6 mmole) in 1,4-dioxane (1 ml), KF (2.57 g, 44.3 mmole) and 2-fluoro-4-methylbenzeneboronic acid (step 31.1, 2.68 g, 17.45 mmole). The resulting mixture is heated at 120° C. for 48 h. The reaction mixture is filtered through celite and washed pad with EtOAc. The filtrate is washed with H2O, dried over MgSO4 (anhydrous) and evaporated under reduced pressure to give a brown solid, which is purified by chromatography, affording the title product.

1. filtrationThe reaction mixture is filtered through celite
2. washwashed pad with EtOAc
3. washThe filtrate is washed with H2O
4. dry with materialdried over MgSO4 (anhydrous)
5. customevaporated under reduced pressure
6. customto give a brown solid, which
7. customis purified by chromatography