Potassium Carbonate → HCID 86668810, compound

HRID 1472050Notes

Reaction equation

HRID 1472050 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([CH3:9])[N:3]=1.[CH3:10][P:11]([C:14]1[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=1)([CH3:13])=[O:12].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:8][C:6]1[N:5]=[C:4]([CH3:9])[N:3]=[C:2]([NH:18][C:17]2[CH:16]=[CH:15][C:14]([P:11]([CH3:13])([CH3:10])=[O:12])=[CH:20][CH:19]=2)[CH:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 2349974,6-Dichloro-2-methylpyrimidineHCID 206345534-(Dimethylphosphoryl)aniline

Product 1

HCID 86668810HCID 86668810, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 4,6-dichloro-2-methylpyrimidine (1.31 mmol) in 1 mL of DMF is added 4-(dimethylphosphoryl) aniline (0.221 g, 1.31 mmol) and potassium carbonate (0.217 g, 1.57 mmol). The mixture is heated at 110° C. until formation of the desired compound. The reaction mixture is basified with saturated sodium bicarbonate solution. The suspension is filtered and washed with ethyl acetate.

Sources & evidence

ORD record
ord-6e5534fb590b4dd2a4fc8c2f978cf29a
Source dataset
uspto-grants-2015_04
Patent number
US09012462B2

Reaction notes

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