Hydrochloric Acid → HCID 16875682, compound

HRID 1472204Notes

Reaction equation

HRID 1472204 reaction equation
C[O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)=[C:6]([N+:17]([O-:19])=[O:18])[CH:5]=1.[ClH:21]>>[ClH:21].[CH3:16][N:13]1[CH2:14][CH2:15][N:10]([C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:20])=[O:2])=[CH:5][C:6]=2[N+:17]([O-:19])=[O:18])[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 2904229Methyl 4-(4-methylpiperazin-1-yl)-3-nitrobenzoate

Product 1

HCID 16875682HCID 16875682, compound

Procedure

A solution of 4-(4-methyl-piperazin-1-yl)-3-nitro-benzoic acid methyl ester (1.8 g, 6.4 mmol) in 35 mL of 5N HCl was stirred at 55° C. for 16 h. The reaction mixture was then evaporated to dryness affording the title compound (quantitative) that was used for the next step without any further purification.

Workup

  1. customThe reaction mixture was then evaporated to dryness

Sources & evidence

ORD record
ord-b261e6031b1d4ce8b069f04ecf68ee10
Source dataset
uspto-grants-2015_04
Patent number
US09012487B2

Reaction notes

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