反应详情

温度

0 °C

An oven-dried round-bottomed flask was charged with 4,5-dibromothiophene-2-carboxamide (4.28 g, 15.0 mmol) and 20 mL of DMF under an argon atmosphere. The solution was cooled on an ice-water bath, and cyanuric chloride (1.81 g, 9.8 mmol) was then added in one portion. After stirring at 0° C. for 1 h, the reaction mixture was warmed to room temperature, and stirred for a further 3 h. 100 mL of water was added. A white solid was formed, which was collected through suction filtration, washed with water, and dried together with phosphorous pentoxide under vacuum to afford 3.70 g (92%) of product.

1. temperatureThe solution was cooled on an ice-water bath
2. temperaturethe reaction mixture was warmed to room temperature
3. stirringstirred for a further 3 h
4. customA white solid was formed
5. filtrationwhich was collected through suction filtration
6. washwashed with water
7. dry with materialdried together with phosphorous pentoxide under vacuum