Potassium Carbonate → HCID 59589653, compound

HRID 1472836Notes

Reaction equation

[CH2:1](Br)[CH:2]1[O:6][CH2:5][CH2:4][CH2:3]1.[N:8]1([CH2:13][CH2:14][O:15][C:16]2[CH:21]=[CH:20][C:19]([NH:22][C:23]3[N:38]=[C:26]4[CH:27]=[CH:28][CH:29]=[C:30]([C:31]5[CH:32]=[C:33]([OH:37])[CH:34]=[CH:35][CH:36]=5)[N:25]4[N:24]=3)=[CH:18][CH:17]=2)[CH2:12][CH2:11][CH2:10][CH2:9]1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[N:8]1([CH2:13][CH2:14][O:15][C:16]2[CH:21]=[CH:20][C:19]([NH:22][C:23]3[N:38]=[C:26]4[CH:27]=[CH:28][CH:29]=[C:30]([C:31]5[CH:36]=[CH:35][CH:34]=[C:33]([O:37][CH2:1][CH:2]6[CH2:3][CH2:4][CH2:5][O:6]6)[CH:32]=5)[N:25]4[N:24]=3)=[CH:18][CH:17]=2)[CH2:9][CH2:10][CH2:11][CH2:12]1

Participants

Conditions

Temperature: 80 °C

Procedure

Tetrahydrofurfuryl bromide (20 mg, 0.18 mmol) was added to a stirred solution of 3-{2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-phenol (50 mg, 0.12 mmol) and potassium carbonate (25 mg, 0.18 mmol) in dimethylformamide (1.5 ml). The mixture was heated overnight at 80° C. then cooled and transferred to a vial for purification by preparatory HPLC. RT: 2.70 min, MI: 500.22, Method: 2.

Workup

temperaturethen cooled
customvial for purification by preparatory HPLC

Sources & evidence

ORD record: ord-51ba69e86abd446b8991384bc9ce6792
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09012633B2

Reaction notes

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