反应详情

A mixture of 1-tert-Butyl 6-ethyl (2S)-2-[(tert-butoxycarbonyl)amino]-5-(3-fluoropropyl)-hexanedioate (1f) (90.0 mg, 0.22 mmol) and lithium hydroxide (53.0 mg, 2.22 mmol) in 1 mL water/ethanol (1:1) was stirred for 14 h at r.t. The mixture was acidified to pH 2 by addition of 2 N aqueous hydrochloric acid and extracted with ethyl acetate (3×5 mL). The combined organic layers were dried over sodium sulphate and concentrated under reduced pressure.

1. extractionextracted with ethyl acetate (3×5 mL)
2. dry with materialThe combined organic layers were dried over sodium sulphate
3. concentrationconcentrated under reduced pressure