Trifluoroacetic acid → HCID 86678431, compound

HRID 1473718Notes

Reaction equation

HRID 1473718 reaction equation
C(OC([NH:8][C@@H:9]([CH2:17][CH2:18][CH:19]([CH2:23][CH2:24][CH2:25][F:26])[C:20]([OH:22])=[O:21])[C:10]([O:12]C(C)(C)C)=[O:11])=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:8][C@@H:9]([CH2:17][CH2:18][CH:19]([CH2:23][CH2:24][CH2:25][F:26])[C:20]([O-:22])=[O:21])[C:10]([OH:12])=[O:11].[NH4+:8]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86678430HCID 86678430, compound

Product 1

HCID 86678431HCID 86678431, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 1-tert-Butyl 6-hydrogen (2S)-2-[(tert-butoxycarbonyl)amino]-5-(3-fluoropropyl)-hexanedioate (57.0 mg, 0.15 mmol) and trifluoroacetic acid (0.5 mL) and dichloromethane (0.5 mL) was stirred at r.t. for 30 min. Then the mixture was concentrated under reduced pressure and the residue was purified by preparative HPLC (ZIC HILIC, 5 μm 100×4.6 mm, acetonitrile/0.1 M aqueous ammonium formate solution gradient, 10 mL/min).

Workup

  1. concentrationThen the mixture was concentrated under reduced pressure
  2. customthe residue was purified by preparative HPLC (ZIC HILIC, 5 μm 100×4.6 mm, acetonitrile/0.1 M aqueous ammonium formate solution gradient, 10 mL/min)

Sources & evidence

ORD record
ord-ff2856ec28f247b1be4d2534fe0048a4
Source dataset
uspto-grants-2015_04
Patent number
US09017645B2

Reaction notes

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