Hydrochloric Acid → HCID 59496138, compound

HRID 1473956Notes

Reaction equation

HRID 1473956 reaction equation
Cl.C(OC(=O)[NH:8][C:9]1[N:10]=[C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[N:12]2[C:18]=1[C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[CH:20]=1)(C)(C)C.C(OCC)(=O)C>O1CCOCC1>[CH3:17][C:13]1[N:12]2[C:18]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:26])[F:27])[CH:20]=3)=[C:9]([NH2:8])[N:10]=[C:11]2[CH:16]=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 59496140HCID 59496140, compound2×

Product 1

HCID 59496138HCID 59496138, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4 M of Hydrogen chloride in 1,4-dioxane (0.8 mL) was added to [5-Methyl-3-(3-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridin-2-yl]-carbamic acid tert-butyl ester (compound r, 0.14 g, 0.00036 mol). The mixture was stirred at room temperature for 2 hours. Solvent evaporated to give 0.1 g as a yellow oil. Rf 0.42, 100% ethyl acetate; MS m/z 292 (M+H).

Workup

  1. customSolvent evaporated
  2. customto give 0.1 g as a yellow oil

Sources & evidence

ORD record
ord-9195be18747a4ba5aa693a30980eaaa7
Source dataset
uspto-grants-2015_04
Patent number
US09018208B2

Reaction notes

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