反应详情

温度

130 °C

To a 50 mL flask containing a stir bar were added 2-methoxy-4-bromobenzonitrile (0.30 g, 1.4 mmol), palladium tetrakis (82 mg, 0.071 mmol), allyltri-n-butyltin (0.877 mL, 2.83 mmol), and lithium chloride (0.120 g, 2.83 mmol). The resulting mixture was then dissolved in anhydrous toluene (16 mL); the flask was placed in an oil bath and heated at 130° C.; LC as well as TLC (hexanes/EtOAc=1/0.3) indicated that reaction had gone to completion. The flask was taken out of the oil bath and cooled to room temperature. To the flask was poured EtOAc (40 mL) and the mixture was transferred into a separatory funnel and washed with aqueous NaCl. The organic phase was dried over Na2SO4, filtered and concentrated to dryness. It was then dissolved in DCM and absorbed into silica gel. The silica gel was then loaded onto a silica column for separation with the solvent systems of hexanes/EtOAc (1/0.3); this gave 2-(methyloxy)-4-prop-2-en-1-ylbenzonitrile. LC-MS (IE, m/z): 174 [M+1]+; tR=2.10 min.

1. additionTo a 50 mL flask containing a stir bar
2. customthe flask was placed in an oil bath
3. temperaturecooled to room temperature
4. customthe mixture was transferred into a separatory funnel
5. washwashed with aqueous NaCl
6. dry with materialThe organic phase was dried over Na2SO4
7. filtrationfiltered
8. concentrationconcentrated to dryness
9. dissolutionIt was then dissolved in DCM
10. customabsorbed into silica gel
11. customThe silica gel was then loaded onto a silica column for separation with the solvent systems of hexanes/EtOAc (1/0.3)