HCID 59238245, compound → (3-bromo-2,5-dimethylphenyl)methanol

HRID 1474322Notes

Reaction equation

HRID 1474322 reaction equation
[Br:1][C:2]1[C:3]([CH3:12])=[C:4]([CH:8]=[C:9]([CH3:11])[CH:10]=1)[C:5](O)=[O:6]>C1COCC1>[Br:1][C:2]1[C:3]([CH3:12])=[C:4]([CH2:5][OH:6])[CH:8]=[C:9]([CH3:11])[CH:10]=1

Participants

3

Reactant 1

HCID 59238245HCID 59238245, compound

Product 1

HCID 10656303(3-bromo-2,5-dimethylphenyl)methanol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 3-bromo-2,5-dimethylbenzoic acid (3.5 g, 15 mmol) in anhydrous THF was added borane THF complex (1.0 M, 25 mL, 25 mmol) at 0, then the reaction was warmed to ambient temperature overnight. The reaction was quenched with MeOH and concentrated to afford (3-bromo-2,5-dimethylphenyl)methanol.

Workup

  1. customThe reaction was quenched with MeOH
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-7493043f55034c139b232a4efd223ef5
Source dataset
uspto-grants-2015_04
Patent number
US09018211B2

Reaction notes

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