Diisopropylethylamine → HCID 178432966, compound

HRID 1475225Notes

Reaction equation

[CH3:1][C:2]1[N:6]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([N:14]3[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]3)[CH:9]=2)[N:5]=[C:4]([C:21]#[N:22])[N:3]=1.Cl.[NH2:24][OH:25].CCN(C(C)C)C(C)C>CCO>[OH:25][NH:24][C:21]([C:4]1[N:3]=[C:2]([CH3:1])[N:6]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([N:14]3[CH2:15][CH2:16][N:17]([CH3:20])[CH2:18][CH2:19]3)[CH:9]=2)[N:5]=1)=[NH:22]

Participants

Conditions

Temperature: 80 °C

Procedure

To a solution of 5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazole-3-carbonitrile (120 mg, 0.40 mmol) in EtOH (2 mL) was added hydroxylamine hydrochloride (31 mg, 0.44 mmol) and DIPEA (141 μL, 0.81 mmol). The reaction was stirred at 80° C. for 2 h before the solvent was removed under reduced pressure. The crude product was used without further purification. MS (ES+) C16H23N7O requires: 329 found: 330 [M+H]+.

Workup

customwas removed under reduced pressure
customThe crude product was used without further purification

Sources & evidence

ORD record: ord-9d1322f7ecff4871a2618c96b388760e
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09018380B2

Reaction notes

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