反应详情

温度

20 °C

A mixture of 1-acetyl-5-bromo-2,3-dihydro-1H-indole-6-sulfonyl chloride (0.25 g, 0.74 mmol), pyrrolidine (0.156 g, 2.2 mmol) and THF (10 mL) was stirred at 20° C. for 18 h then was partitioned between water (50 mL) and EtOAc (2×50 mL). The combined organic extracts were dried (Na2SO4) and evaporated in vacuo to give a solid. Chromatography (SiO2; gradient elution with 50-100% EtOAc in petrol) gave the title compound (0.206 g) as a colourless solid. MS: [M+H]+=373.

1. customthen was partitioned between water (50 mL) and EtOAc (2×50 mL)
2. dry with materialThe combined organic extracts were dried (Na2SO4)
3. customevaporated in vacuo
4. customto give a solid
5. washChromatography (SiO2; gradient elution with 50-100% EtOAc in petrol)