Hydrochloric Acid → HCID 86723977, compound

HRID 1475366Notes

Reaction equation

HRID 1475366 reaction equation
[C:1]([O:5][C:6]([N:8]1[C:12]2=[CH:13][N:14]=[C:15]([O:17]C)[CH:16]=[C:11]2[C:10]([CH3:20])([CH3:19])[C:9]1=[O:21])=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[CH2:23][C:24]([CH3:26])=[CH2:25].Cl>CCOC(C)=O>[C:1]([O:5][C:6]([N:8]1[C:12]2=[CH:13][N:14]([CH2:25][C:24]([CH3:26])=[CH2:23])[C:15](=[O:17])[CH:16]=[C:11]2[C:10]([CH3:20])([CH3:19])[C:9]1=[O:21])=[O:7])([CH3:3])([CH3:2])[CH3:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3577853-Bromo-2-methyl-1-propeneHCID 86723978HCID 86723978, compound

Product 1

HCID 86723977HCID 86723977, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5-Methoxy-3,3-dimethyl-2-oxo-2,3-dihydro-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester was heated with 3-bromo-2-methylpropene (4 eq.) at 100° C. for 4 h in a reactivial and then allowed to cool. Saturated HCl in EtOAc ˜10 vol) was added and the reaction was stirred for 30 minutes at room temperature. The reaction was then concentrated in vacuo to give the title compound, used without further purification. MS: [M+H]+=333.

Workup

  1. temperatureto cool
  2. concentrationThe reaction was then concentrated in vacuo

Sources & evidence

ORD record
ord-e54a3c758e314d39a2c19c4459e929be
Source dataset
uspto-grants-2015_04
Patent number
US09018214B2

Reaction notes

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