Dimethyl Sulfide → HCID 90231912, compound

HRID 1475396Notes

Reaction equation

HRID 1475396 reaction equation
[CH2:1]([C:8]1([CH3:19])[C:16]2[C:11](=[CH:12][C:13]([Cl:17])=[CH:14][CH:15]=2)[NH:10][C:9]1=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(C)C>>[CH2:1]([C:8]1([CH3:19])[C:16]2[C:11](=[CH:12][C:13]([Cl:17])=[CH:14][CH:15]=2)[NH:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 1068Dimethyl SulfideHCID 70982021HCID 70982021, compound

Product 1

HCID 90231912HCID 90231912, compoundYield 67.4%

Procedure

3-Benzyl-6-chloro-3-methyl-1,3-dihydro-indol-2-one (641 mg) was reduced with BH3.Me2S following a similar method to that described in Preparation 54 to give title compound (410 mg) as a colourless gum. MS: [M+H]+=258.

Sources & evidence

ORD record
ord-47e19044a9534be6b8d1ca76ad3f3ad6
Source dataset
uspto-grants-2015_04
Patent number
US09018214B2

Reaction notes

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