Hydrochloric Acid → HCID 70982087, compound

HRID 1475447Notes

Reaction equation

HRID 1475447 reaction equation
C(OC([N:8]1[C:16]2[CH:15]=[C:14]([C:17]([F:21])([F:20])[CH2:18][CH3:19])[N:13]=[CH:12][C:11]=2[C:10]([CH3:23])([CH3:22])[CH2:9]1)=O)(C)(C)C.[ClH:24]>CO>[ClH:24].[F:20][C:17]([C:14]1[N:13]=[CH:12][C:11]2[C:10]([CH3:22])([CH3:23])[CH2:9][NH:8][C:16]=2[CH:15]=1)([F:21])[CH2:18][CH3:19]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70980231HCID 70980231, compound

Product 1

HCID 70982087HCID 70982087, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
20 °C

Procedure

A mixture of 6-(1,1-difluoro-propyl)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester (0.398 g, 1.2 mmol), hydrochloric acid (5 M, 12 mL) and methanol (12 mL) was stirred at 20° C. for 16 h then evaporated in vacuo. The residue was azeotroped with methanol (×3) and toluene (×2) to give the title compound (0.3 g) as a solid. MS: [M+H]+=227.

Workup

  1. customthen evaporated in vacuo
  2. customThe residue was azeotroped with methanol (×3) and toluene (×2)

Sources & evidence

ORD record
ord-16479b272eab41a4b3b05147945606f8
Source dataset
uspto-grants-2015_04
Patent number
US09018214B2

Reaction notes

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