HCID 70980247, compound → HCID 70980544, compound

HRID 1475460Notes

Reaction equation

HRID 1475460 reaction equation
C[O:2][C:3](=O)[C:4]([C:12]1[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][C:13]=1[N+:19]([O-])=O)([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH3:5]>[Fe]>[Br:18][C:15]1[CH:14]=[C:13]2[C:12]([C:4]([CH3:5])([C:6]3[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=3)[C:3](=[O:2])[NH:19]2)=[CH:17][CH:16]=1

Participants

3

Reactant 1

HCID 70980247HCID 70980247, compound

Product 1

HCID 70980544HCID 70980544, compoundYield 59.1%

Reagents, catalysts & solvents 1

HCID 23925IronCatalyst

Procedure

Following similar methods to those described in Preparation 326 starting from 2-(4-bromo-2-nitro-phenyl)-2-phenyl-propionic acid methyl ester (1.3 g, 4.9 mmol) and iron powder (890 mg, 15 mmol) gave the title compound (875 mg) as a yellow solid. MS: [M+H]+=302.

Sources & evidence

ORD record
ord-7caa7c29231e4844bf46e8524517a9bf
Source dataset
uspto-grants-2015_04
Patent number
US09018214B2

Reaction notes

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