Trifluoroacetic acid → HCID 86667527, compound

HRID 1475682Notes

Reaction equation

HRID 1475682 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][C:7]2([C:10]([O:12]C(C)(C)C)=[O:11])[CH2:9][CH2:8]2)=[C:4]([F:19])[C:3]=1[NH:20][C:21](=[O:36])[C@H:22]([C:29]1[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=1)[C@@H:23]([CH3:28])[C:24]([F:27])([F:26])[F:25].C(O)(C(F)(F)F)=O>ClCCl>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([CH2:6][C:7]2([C:10]([OH:12])=[O:11])[CH2:9][CH2:8]2)=[C:4]([F:19])[C:3]=1[NH:20][C:21](=[O:36])[C@H:22]([C:29]1[CH:30]=[CH:31][C:32]([Cl:35])=[CH:33][CH:34]=1)[C@@H:23]([CH3:28])[C:24]([F:27])([F:26])[F:25]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86667524HCID 86667524, compound

Product 1

HCID 86667527HCID 86667527, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

22.0 mg (0.040 mmol) of tert-butyl 1-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-2-fluorobenzyl)cyclopropanecarboxylate were dissolved in 0.19 ml of dichloromethane, and 0.5 ml of TFA was added at RT. After 1 h at RT, the reaction mixture was concentrated under reduced pressure and the residue was dried under high vacuum overnight. This gave 17.8 mg (82.2% of theory) of the target compound.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. customthe residue was dried under high vacuum overnight

Sources & evidence

ORD record
ord-66d11daa6b764100ae69efaf32b9d2b3
Source dataset
uspto-grants-2015_04
Patent number
US09018258B2

Reaction notes

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