Potassium Carbonate → 1-(4-Chloro-3-hydroxy-benzoylamino)-cycloheptanecarboxylic acid methyl ester

HRID 1475711Notes

Reaction equation

HRID 1475711 reaction equation
[CH3:1][O:2][C:3]([C:5]1([NH:12][C:13](=[O:25])[C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([O:21]C(=O)C)[CH:15]=2)[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1)=[O:4].C(=O)([O-])[O-].[K+].[K+]>CO>[CH3:1][O:2][C:3]([C:5]1([NH:12][C:13](=[O:25])[C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([OH:21])[CH:15]=2)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]1)=[O:4]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 671708791-(3-Acetoxy-4-chloro-benzoylamino)-cycloheptanecarboxylic Acid Methyl Ester

Product 1

HCID 671703841-(4-Chloro-3-hydroxy-benzoylamino)-cycloheptanecarboxylic acid methyl esterYield 84.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound of step 2 (400 mg, 1.088 mmol) was dissolved in methanol (3.5 ml), potassium carbonate (3 mg, 0.02 mmol) was added, and the mixture was stirred at room temperature for 6 h and evaporated to dryness to yield the title compound (300 mg).

Workup

  1. customevaporated to dryness

Sources & evidence

ORD record
ord-b83aa1cd4441487eb4b71efc88ed9774
Source dataset
uspto-grants-2015_04
Patent number
US09018383B2

Reaction notes

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