Sodium hydride → HCID 53240895, compound

HRID 1475962Notes

Reaction equation

[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11](Cl)(=[O:13])=[O:12])(=[O:4])=[O:3].[H-].[Na+].[C:17]([O:20][NH:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])(=[O:19])[CH3:18]>>[C:17]([O:20][N:21]([S:11]([C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[S:2]([CH3:1])(=[O:4])=[O:3])(=[O:13])=[O:12])[C:22](=[O:23])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])(=[O:19])[CH3:18]

Participants

Reactant 3

HCID 24758Sodium hydride

HCID 27351782-Methanesulfonylbenzene-1-sulfonyl chloride

HCID 10058028(ACETYLOXY)-CARBAMIC ACID TERT-BUTYL ESTER

Product 1

HCID 53240895HCID 53240895, compound

Procedure

tert-Butyl (acetyloxy){[2-(methylsulfonyl)phenyl]sulfonyl}carbamate (42) is prepared from 2-methylsulfonylbenzenesulfonyl chloride, sodium hydride and [(tert-butoxy)carbonyl]amino acetate according to Scheme 2. (0.5 g, 16%), 1H NMR (400 MHz, DMSO-d6) δ ppm 8.26-8.34 (1H, m), 8.17-8.25 (1H, m), 8.03-8.11 (2H, m), 3.46 (3H, s), 2.32 (3H, s), 1.28 (9H, s).

Sources & evidence

ORD record: ord-fc792dcd52e44b03ac1673f1773b6cfd
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09018411B2

Reaction notes

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