Isobutyryl chloride → HCID 57211324, compound

HRID 1475966Notes

Reaction equation

[C:1](Cl)(=[O:5])[CH:2]([CH3:4])[CH3:3].[C:7]([O:11][C:12]([NH:14][OH:15])=[O:13])([CH3:10])([CH3:9])[CH3:8]>>[CH3:3][CH:2]([CH3:4])[C:1]([O:15][NH:14][C:12]([O:11][C:7]([CH3:10])([CH3:9])[CH3:8])=[O:13])=[O:5]

Participants

Reactant 2

HCID 62325Isobutyryl chloride

HCID 97534tert-butyl N-hydroxycarbamate

Product 1

HCID 57211324HCID 57211324, compound

Procedure

[(tert-Butoxy)carbonyl]amino 2-methylpropanoate is prepared from isobutyryl chloride and N-tert-butoxycarbonyl hydroxylamine according to Scheme 1 using the method described by Carpino et al. J. Am. Chem. Soc. 1959, 955-957. (6.36 g, 83%), 1H NMR (250 MHz, DMSO-d6) δ ppm 10.51 (1H, br. s.), 2.65 (1H, sept, 7.0 Hz), 1.40 (9H, s), 1.13 (6H, d, 7.0 Hz).

Sources & evidence

ORD record: ord-390008dbd7bf475ba18215471cb5aaa3
Source dataset: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09018411B2

Reaction notes

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