Sodium hydride → HCID 53240983, compound

HRID 1475969Notes

Reaction equation

HRID 1475969 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11](Cl)(=[O:13])=[O:12])(=[O:4])=[O:3].[H-].[Na+].[CH3:17][C:18]([CH3:31])([CH3:30])[C:19]([O:21][NH:22][C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])=[O:20]>>[CH3:17][C:18]([CH3:31])([CH3:30])[C:19]([O:21][N:22]([S:11]([C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=1[S:2]([CH3:1])(=[O:4])=[O:3])(=[O:13])=[O:12])[C:23](=[O:24])[O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:20]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 300008[(tert-Butoxy)carbonyl]amino 2,2-dimethylpropanoateHCID 27351782-Methanesulfonylbenzene-1-sulfonyl chloride

Product 1

HCID 53240983HCID 53240983, compound

Procedure

tert-Butyl [(2,2-dimethylpropanoyl)oxy]{[2-(methylsulfonyl)phenyl]sulfonyl}carbamate (46) is prepared from 2-methylsulfonylbenzenesulfonyl chloride, sodium hydride and [(tert-butoxy)carbonyl]amino 2,2-dimethylpropanoate according to Scheme 2. (1.5 g, 78%), 1H NMR (250 MHz, DMSO-d6) δ ppm 8.18-8.37 (2H, m), 7.94-8.15 (2H, m), 3.46 (3H, s), 1.30 (9H, s), 1.29 (9H, s).

Sources & evidence

ORD record
ord-75d80f516175409c9a19279344826325
Source dataset
uspto-grants-2015_04
Patent number
US09018411B2

Reaction notes

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