Sodium hydride → HCID 53240984, compound

HRID 1475971Notes

Reaction equation

HRID 1475971 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11](Cl)(=[O:13])=[O:12])(=[O:4])=[O:3].[H-].[Na+].[C:17]([O:25][NH:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11]([N:26]([O:25][C:17]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:24])[C:27](=[O:28])[O:29][C:30]([CH3:33])([CH3:32])[CH3:31])(=[O:13])=[O:12])(=[O:4])=[O:3]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 27351782-Methanesulfonylbenzene-1-sulfonyl chlorideHCID 10037153tert-Butyl benzoyloxycarbamate

Product 1

HCID 53240984HCID 53240984, compound

Procedure

tert-Butyl {[2-(methylsulfonyl)phenyl]sulfonyl}[(phenylcarbonyl)oxy]carbamate (47) is prepared from 2-methylsulfonylbenzenesulfonyl chloride, sodium hydride and [(tert-butoxy)carbonyl]amino benzoate according to Scheme 2. (1.7 g, 91%), 1H NMR (250 MHz, DMSO-d6) δ ppm 8.25-8.45 (2H, m), 8.03-8.20 (4H, m), 7.77-7.93 (1H, m), 7.59-7.73 (2H, m), 3.48 (3H, s), 1.29 (9H, s).

Sources & evidence

ORD record
ord-7f2d23720aac495c9611513e86f97743
Source dataset
uspto-grants-2015_04
Patent number
US09018411B2

Reaction notes

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