Pyridine → HCID 86654180, compound

4-{[({[(tert-Butoxy)carbonyl]amino}oxy)carbonyl]oxy}oxane is prepared according to Scheme 9. To a solution of tetrahydropyran-4-ol (2 g, 19.6 mmol) in THF (20 mL) cooled to 5° C. is sequentially added a 20% solution of phosgene in toluene (10.3 mL, 19.6 mmol) and pyridine (1.6 mL, 19.6 mmol). The reaction is stirred for 5 minutes before addition of tert-butyl N-hydroxycarbamate (2.6 g, 19.6 mmol) and pyridine (1.6 mL, 19.6 mmol). Stirring is continued for 30 minutes at room temperature before the reaction mixture is filtered through Celite™ and the resulting organics concentrated in vacuo. The crude reaction is diluted with diethyl ether (50 mL), washed with 0.1N HCl (10 ml) and water (10 ml), dried over sodium sulfate, filtered and concentrated in vacuo. Purification is achieved by silica gel column chromatography eluting with heptane: ethyl acetate (1:1; v:v) to yield the title compound as a clear, colourless oil. (3.64 g, 71%), 1H NMR (500 MHz, CHLOROFORM-d) δ ppm 7.78 (1H, s), 4.92 (1H, tt, 8.4, 4.0 Hz), 3.88-3.98 (2H, m), 3.55 (2H, ddd, 11.8, 8.7, 3.1 Hz), 1.98-2.09 (2H, m), 1.80 (2H, m), 1.50 (9H, s).

1. filtrationis filtered through Celite™
2. concentrationthe resulting organics concentrated in vacuo
3. customThe crude reaction
4. washwashed with 0.1N HCl (10 ml) and water (10 ml)
5. dry with materialdried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated in vacuo
8. customPurification
9. washeluting with heptane: ethyl acetate (1:1; v:v)

ORD record

ord-01c4327184cc48509aa775dcd588a0e2

Source dataset

uspto-grants-2015_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09018411B2