Trifluoroacetic acid → HCID 58288214, compound

HRID 1476142Notes

Reaction equation

HRID 1476142 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([C@@H:29]([CH3:34])[C:30]([F:33])([F:32])[F:31])[C:9]([NH:11][C:12]2[CH:13]=[C:14]([CH2:20][CH2:21][C:22]([O:24]C(C)(C)C)=[O:23])[CH:15]=[CH:16][C:17]=2[C:18]#[N:19])=[O:10])=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]([C@@H:29]([CH3:34])[C:30]([F:31])([F:32])[F:33])[C:9]([NH:11][C:12]2[CH:13]=[C:14]([CH2:20][CH2:21][C:22]([OH:24])=[O:23])[CH:15]=[CH:16][C:17]=2[C:18]#[N:19])=[O:10])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58288339HCID 58288339, compound

Product 1

HCID 58288214HCID 58288214, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

16.5 mg (33 μmol) of tert-butyl 3-(3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}-4-cyanophenyl)propanoate were dissolved in 1.1 ml of dichloromethane, and 275 μl of trifluoroacetic acid were added. The reaction mixture was stirred at RT for 1.5 h, then diluted with 20 ml of dichloromethane and concentrated under reduced pressure. The residue was dried under high vacuum overnight. This gave 14.8 mg (97% of theory) of the title compound.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe residue was dried under high vacuum overnight

Sources & evidence

ORD record
ord-7ee4a476f88c4859b0b8a069ae130676
Source dataset
uspto-grants-2015_04
Patent number
US09018414B2

Reaction notes

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