Trifluoroacetic acid → HCID 67258342, compound

HRID 1476609Notes

Reaction equation

HRID 1476609 reaction equation
[CH3:1][C:2]1[S:3][C:4]([CH2:7][N:8]2[C:13]3[CH:14]=[C:15]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[S:16][C:12]=3[C:11](=[O:23])[N:10]([CH:24]3[CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26][CH2:25]3)[C:9]2=[O:37])=[CH:5][N:6]=1.[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41]>C(Cl)Cl>[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41].[CH3:1][C:2]1[S:3][C:4]([CH2:7][N:8]2[C:13]3[CH:14]=[C:15]([C:17]4[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=4)[S:16][C:12]=3[C:11](=[O:23])[N:10]([CH:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)[C:9]2=[O:37])=[CH:5][N:6]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67257488HCID 67257488, compound

Product 1

HCID 67258342HCID 67258342, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of tert-butyl 4-{1-[(2-methyl-1,3-thiazol-5-yl)methyl]-2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl}piperidine-1-carboxylate (715 mg; compound B20) in DCM (15 ml) is reacted with trifluoroacetic acid (3 ml) according to the procedure described in example B43 to afford the title compound as a solid.

Sources & evidence

ORD record
ord-699eaa8faa51403aa7aec21251dadc5b
Source dataset
uspto-grants-2015_04
Patent number
US09018175B2

Reaction notes

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