Potassium Carbonate → HCID 67258439, compound

HRID 1476636Notes

Reaction equation

HRID 1476636 reaction equation
[O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[S:10][C:5]=2[C:4](=[O:17])[N:3]1[CH:18]1[CH2:23][CH2:22][N:21]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:20][CH2:19]1.Cl[CH2:32][C:33]1[S:34][CH:35]=[CH:36][C:37]=1[CH3:38].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:38][C:37]1[CH:36]=[CH:35][S:34][C:33]=1[CH2:32][N:7]1[C:6]2[CH:8]=[C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[S:10][C:5]=2[C:4](=[O:17])[N:3]([CH:18]2[CH2:23][CH2:22][N:21]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:20][CH2:19]2)[C:2]1=[O:1]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 13979509HCID 13979509, compoundHCID 67257815tert-butyl 4-(2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)piperidine-1-carboxylate

Product 1

HCID 67258439HCID 67258439, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

According to the procedure described for compound B71 tert-butyl 4-(2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)piperidine-1-carboxylate (1.09 g, compound B50) is reacted with 2-(chloromethyl)-3-methylthiophene (410 mg, compound D28) in the presence of potassium carbonate (778 mg) in dry DMF (14 ml) for 1 h at 100° C. to afford the title compound as a solid.

Sources & evidence

ORD record
ord-7d4429265d4043e780f609768c5fc23e
Source dataset
uspto-grants-2015_04
Patent number
US09018175B2

Reaction notes

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