Hydrochloric Acid → HCID 67258926, compound

HRID 1476653Notes

Reaction equation

HRID 1476653 reaction equation
[CH3:1][N:2]1[CH:6]=[N:5][C:4]([CH2:7][N:8]2[C:13]3[CH:14]=[C:15]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[S:16][C:12]=3[C:11](=[O:23])[N:10]([CH:24]3[CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26][CH2:25]3)[C:9]2=[O:37])=[N:3]1.[ClH:38]>O1CCOCC1>[ClH:38].[CH3:1][N:2]1[CH:6]=[N:5][C:4]([CH2:7][N:8]2[C:13]3[CH:14]=[C:15]([C:17]4[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=4)[S:16][C:12]=3[C:11](=[O:23])[N:10]([CH:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)[C:9]2=[O:37])=[N:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67257498tert-butyl 4-{1-[(1-methyl-1H-1,2,4-triazol-3-yl)methyl]-2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl}piperidine-1-carboxylate

Product 1

HCID 67258926HCID 67258926, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of tert-butyl 4-{1-[(1-methyl-1H-1,2,4-triazol-3-yl)methyl]-2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl}piperidine-1-carboxylate (944 mg, compound B70) in 1,4-dioxane (25 ml) is added a solution of hydrogen chloride in 1,4-dioxane (5.0 ml, 6.8 M). The reaction mixture is stirred for 17 h at RT. The resulting precipitate is filtered off, washed with diethyl ether and dried in vacuo to afford the title compound as a solid.

Workup

  1. filtrationThe resulting precipitate is filtered off
  2. washwashed with diethyl ether
  3. customdried in vacuo

Sources & evidence

ORD record
ord-7c6a0609bb1e475c806473650ae8e74a
Source dataset
uspto-grants-2015_04
Patent number
US09018175B2

Reaction notes

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