Hydrochloric Acid → HCID 67259962, compound

HRID 1476658Notes

Reaction equation

HRID 1476658 reaction equation
[CH2:1]([C:3]1[N:4]=[N:5][N:6]([CH2:8][N:9]2[C:14]3[CH:15]=[C:16]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[S:17][C:13]=3[C:12](=[O:24])[N:11]([CH:25]3[CH2:30][CH2:29][N:28](C(OC(C)(C)C)=O)[CH2:27][CH2:26]3)[C:10]2=[O:38])[N:7]=1)[CH3:2].[ClH:39]>O1CCOCC1>[ClH:39].[CH2:1]([C:3]1[N:4]=[N:5][N:6]([CH2:8][N:9]2[C:14]3[CH:15]=[C:16]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[S:17][C:13]=3[C:12](=[O:24])[N:11]([CH:25]3[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]3)[C:10]2=[O:38])[N:7]=1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67257980tert-butyl 4-{1-[(5-ethyl-2H-tetrazol-2-yl)methyl]-2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl}piperidine-1-carboxylate

Product 1

HCID 67259962HCID 67259962, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

According to the procedure described for compound B90 tert-butyl 4-{1-[(5-ethyl-2H-tetrazol-2-yl)methyl]-2,4-dioxo-6-phenyl-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl}piperidine-1-carboxylate (290 mg, compound B75) is reacted with hydrogen chloride in 1,4-dioxane (5.0 ml, 6.8 M) to afford the title compound as a solid.

Sources & evidence

ORD record
ord-3fef938b0be7428bb2972544a1dd01ae
Source dataset
uspto-grants-2015_04
Patent number
US09018175B2

Reaction notes

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