Tetrahydrofuran → HCID 86303505, compound

To a solution of furan-2-ylethynyl)trimethylsilane (100 mg, 0.6097 mmol), phenyl azide (0.5 M solution, 2.42 ml, 1.2195 mmol), and CuI (116.11 mg, 0.6097 mmol) in THF (2 ml) was added 1,1,4,7,7-pentamethyldiethlene triamine (0.254 ml, 1.2195 mmol) and 1M TBAF.3H2O (1.20 ml, 1.2195 mmol). After stirring the reaction mixture for 20 hours at room temperature, it was quenched with saturated ammonium chloride solution and was extracted with ethyl acetate. The combined organic layers were washed with water, dried over anhydrous sodium sulfate and evaporated. The crude material was purified by column chromatography (100-200 mesh silica gel) using 5% ethyl acetate in hexane as eluent to yield 4-(furan-2-yl)-1-phenyl-1H-1,2,3-triazole (80 mg, 0.378 mmol, yield 62.18%) with an HPLC purity of 98.82%. LC-MS [M+H] 212 (C12H9N3O+H expected 212.07), mp 118-120° C. The 1H-NMR spectra was in accordance with the chemical structure.

1. customit was quenched with saturated ammonium chloride solution
2. extractionwas extracted with ethyl acetate
3. washThe combined organic layers were washed with water
4. dry with materialdried over anhydrous sodium sulfate
5. customevaporated
6. customThe crude material was purified by column chromatography (100-200 mesh silica gel)

ORD record

ord-1242d02907a944959b074b927006b1df

Source dataset

uspto-grants-2016_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09402397B2