反应详情

A mixture of methanol (50 ml) and water (50 ml) was acidified with hydrochloric acid (37%, 0.2 ml) and mixed with an aqueous solution of dimethylamine (40%, 11.5 ml, 91 mmol) with ice cooling and stirring. Then 4-dimethylamino-4-phenylcyclohexanone (2.17 g, 10 mmol) and KCN (1.6 g, 24.6 mmol) were added to the solution. A clear solution was formed after 15 min. The ice cooling was removed and the batch stirred for 2.5 h at RT, and a white solid began to separate out after approx. 1 h. The batch was brought to approx. 0° C. again for 1 h by means of ice cooling to complete the precipitation. The precipitate was then separated by means of a fritted glass filter and dried in a vacuum at a bath temperature of 40° C. A diastereoisomer mixture of the title compound was obtained with a yield of 1.83 g (67%) and a melting point of 82-92° C.

1. customA clear solution was formed after 15 min
2. customThe ice cooling was removed
3. stirringthe batch stirred for 2.5 h at RT
4. customto separate out after approx. 1 h
5. customthe precipitation
6. customThe precipitate was then separated by means of a fritted glass
7. filtrationfilter
8. customdried in a vacuum at a bath temperature of 40° C
9. additionA diastereoisomer mixture of the title compound
10. customwas obtained with a yield of 1.83 g (67%)