Dichloromethane → HCID 178462646, compound

HRID 1477490Notes

Reaction equation

[CH3:1][C:2]1([CH3:30])[CH2:7][CH2:6][C:5]([C:8]2[C:13]([NH:14][C:15]([C:17]3[NH:18][CH:19]=[C:20]([C:22]#[N:23])[N:21]=3)=[O:16])=[CH:12][CH:11]=[C:10]([C:24]3(O)[CH2:28][CH2:27][CH2:26][CH2:25]3)N=2)=[CH:4][CH2:3]1.[CH2:31]([N:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1)[CH3:32].S(Cl)(Cl)=O.[CH2:43](Cl)Cl>>[CH3:1][C:2]1([CH3:30])[CH2:7][CH2:6][C:5]([C:8]2[CH:43]=[C:10]([C:24]3([N:36]4[CH2:37][CH2:38][N:33]([CH2:31][CH3:32])[CH2:34][CH2:35]4)[CH2:25][CH2:26][CH2:27][CH2:28]3)[CH:11]=[CH:12][C:13]=2[NH:14][C:15]([C:17]2[NH:23][CH:22]=[C:20]([C:19]#[N:18])[N:21]=2)=[O:16])=[CH:4][CH2:3]1

Participants

Reactant 4

HCID 6344Dichloromethane

HCID 24386Thionyl Chloride

HCID 791961-Ethylpiperazine

HCID 178424653HCID 178424653, compound

Product 1

HCID 178462646HCID 178462646, compound

Procedure

The title compound is prepared from 4-cyano-1H-imidazole-2-carboxylic acid [2-(4,4-dimethyl-cyclohex-1-enyl)-6-(1-hydroxy-cyclopentyl)-pyridin-3-yl]-amide (as prepared in the previous step), N-ethylpiperazine, and thionyl chloride in DCM solvent according to the procedure in Example 43.

Sources & evidence

ORD record: ord-5c9590aad18d4e22814c6a46aa03ad52
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09403804B2

Reaction notes

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