HCID 136954683, compound → HCID 178452267, compound

HRID 1477569Notes

Reaction equation

HRID 1477569 reaction equation
Cl[C:2]1[NH:3][C:4](=[O:21])[N:5]=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]2)[N:7]=1>[OH-].[Pd+2].[OH-]>[O:21]=[C:4]1[NH:3][CH:2]=[N:7][C:6]([N:8]2[CH2:9][CH2:10][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:12][CH2:13]2)=[N:5]1

Participants

3

Reactant 1

HCID 136954683HCID 136954683, compound

Product 1

HCID 178452267HCID 178452267, compound

Reagents, catalysts & solvents 1

HCID 9942167Palladium hydroxideCatalyst

Procedure

tert-Butyl 4-(6-chloro-4-oxo-4,5-dihydro-1,3,5-triazin-2-yl)piperazine-1-carboxylate (14.2 g, 45.0 mmol) synthesized in Reference Synthesis Example 6 and palladium hydroxide-activated carbon catalyst (142 mg) were used to obtain a crude product of the title compound by synthesis in a similar manner to Reference Synthesis Example 3. The crude product was used in the next reaction as it was.

Sources & evidence

ORD record
ord-988b6248acd648f6975c5479586ebd03
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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