6-Chloro-4-[4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl]-1,3,5-triazin-2(1H)-one → HCID 178517888, compound

HRID 1477579Notes

Reaction equation

HRID 1477579 reaction equation
Cl[C:2]1[NH:7][C:6](=[O:8])[N:5]=[C:4]([N:9]2[CH2:14][CH2:13][C:12]([C:16]3[CH:21]=[CH:20][C:19](Cl)=[CH:18][CH:17]=3)([OH:15])[CH2:11][CH2:10]2)[N:3]=1>[OH-].[Pd+2].[OH-]>[OH:15][C:12]1([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:11][CH2:10][N:9]([C:4]2[N:3]=[CH:2][NH:7][C:6](=[O:8])[N:5]=2)[CH2:14][CH2:13]1

Participants

3

Reactant 1

HCID 1369330506-Chloro-4-[4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl]-1,3,5-triazin-2(1H)-one

Product 1

HCID 178517888HCID 178517888, compound

Reagents, catalysts & solvents 1

HCID 9942167Palladium hydroxideCatalyst

Procedure

6-Chloro-4-[4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl]-1,3,5-triazin-2(1H)-one (341 mg, 1.00 mmol) synthesized in Reference Synthesis Example 21 and palladium hydroxide-activated carbon catalyst (34.1 mg) were used to obtain a mixture of compounds of Reference Synthesis Example 22a and Reference Synthesis Example 22b being the title compounds (424 mg, quantitative) by synthesis in a similar manner to Reference Synthesis Example 3.

Workup

  1. customto obtain
  2. additiona mixture of compounds of Reference Synthesis Example 22a and Reference Synthesis Example 22b
  3. customby synthesis in a similar manner
  4. customto Reference Synthesis Example 3

Sources & evidence

ORD record
ord-3a0c794ffc7f4b99abb475cd4d1793e5
Source dataset
uspto-grants-2016_08
Patent number
US09403798B2

Reaction notes

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